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Publications

(see also https://www.ncbi.nlm.nih.gov/pubmed/?term=crüsemann+m)

Publikationen 

28. Malfacini, D., Patt, J., Annala, S., Harpsøe, K., Eryilmaz, F., Reher, R., Crüsemann, M., Hanke, W., Zhang, H., Tietze, D., Gloriam, D.E., Bräuner-Osborne, H., Strømgaard, K., König, G.M., Inoue, A., Gomeza, J., Kostenis, E: Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity. J Biol Chem 2019 294, 5747-5758.

27. Linares-Otoya, L., Liu, Y., Linares-Otoya, V., Armas-Mantilla, L., Crüsemann, M., Ganoza-Yupanqui, M.L., Campos-Florian, J., König, G.M., Schäberle, T.F.: Biosynthetic Basis for Structural Diversity of Aminophenylpyrrole-Derived Alkaloids. ACS Chem Biol 2019 14, 176–181.

26. Amiri Moghaddam, J., Crüsemann, M., Alanjary, M., Harms, H., Dávila-Céspedes, A., Blom, J, Poehlein, A., Ziemert, N, M. König, G.M., Schäberle, T.F. Analysis of the Genome and Metabolome of Marine Myxobacteria Reveals High Potential for Biosynthesis of Novel Specialized Metabolites. Sci Rep 2018, 8 16600

25. Amiri Moghaddam, J., Dávila-Céspedes, A., Kehraus, S., Crüsemann, M., Köse, M., Müller, C.E., König, G.M. Cyclopropane-Containing Fatty Acids from the Marine Bacterium Labrenzia sp. 011 with Antimicrobial and GPR84 Activity. Mar Drugs 2018 16, pii: E369.

24. Harms, H., Klöckner, A., Schrör, J., Josten, M., Kehraus, S., Crüsemann, M., Hanke, W., Schneider, T., Schäberle, T.F., König, G.M. Antimicrobial Dialkylresorcins from Marine-Derived Microorganisms: Insights into Their Mode of Action and Putative Ecological Relevance. Planta Med 2018 Jul 10. doi: 10.1055/a-0653-7451.

23. Reher, R., Kuschak, M., Heycke, N., Annala, S., Kehraus, S., Dai, H-F., Müller, C.E., Kostenis, E., König, G.M., Crüsemann, M., Applying Molecular Networking for the Detection of Natural Sources and Analogues of the Selective Gq Protein Inhibitor FR900359. J Nat Prod 2018 81, 1628-1635.

22. Reher, R., Kühl, T., Annala, S., Benkel, T., Kaufmann, D., Nubbemeyer, B., Odhiambo, J.P., Heimer, P., Bäuml, C.A., Kehraus, S., Crüsemann, M., Kostenis, E., Tietze, D., König, G.M. and Imhof, D., Deciphering specificity determinants for FR900359-derived Gαq inhibitors based on computational and structure-activity studies. ChemMedChem 2018 13, 1634-1643. Featured on Front Cover

21.
a) Crüsemann, M., Reher, R., Schamari, I., Brachmann, A.O., Ohbayashi, T., Kuschak, M., Malfacini, D., Seidinger, A., Pinto-Carbó, M., Richarz, R., Reuter, T., Kehraus, S., Hallab, A., Attwood, M., Schiöth, H.B., Mergaert, P., Kikuchi, Y., Schäberle, T.F., Kostenis, E., Wenzel, D., Müller, C.E., Piel, J., Carlier, A., Eberl, L., König, G.M. Heterologous expression, biosynthetic studies and ecological function of the selective Gq-signaling inhibitor FR900359. Angew Chem Int Ed Engl. 2017 Dec 1. doi: 10.1002/anie.201707996.

b) Crüsemann, M., Reher, R., Schamari, I., Brachmann, A.O., Ohbayashi, T., Kuschak, M., Malfacini, D., Seidinger, A., Pinto-Carbó, M., Richarz, R., Reuter, T., Kehraus, S., Hallab, A., Attwood, M., Schiöth, H.B., Mergaert, P., Kikuchi, Y., Schäberle, T.F., Kostenis, E., Wenzel, D., Müller, C.E., Piel, J., Carlier, A., Eberl, L., König, G.M. Heterologe Expression, Biosynthese und ökologische Funktion des selektiven Gq-Signaltransduktionsinhibitors FR900359. Angew Chem. 2017 Dec 1. doi: 10.1002/ange.201707996.

20. Linares-Otoya, L., Linares-Otoya, V., Armas-Mantilla, L., Blanco-Olano, C., Crüsemann, M., Ganoza-Yupanqui, M.L., Campos-Florian, J., König, G.M., Schäberle, T.F.: Diversity and Antimicrobial Potential of Predatory Bacteria from the Peruvian Coastline. Mar. Drugs 2017, 15, 308; doi:10.3390/md15100308

19. Linares-Otoya, L., Linares-Otoya, V., Armas-Mantilla, L., Blanco-Olano, C., Crüsemann, M., Ganoza-Yupanqui, M.L., Campos-Florian, J., König, G.M., Schäberle, T.F.: Identification and heterologous expression of the kocurin biosynthetic gene cluster. Microbiology. 2017 Sep 25. doi: 10.1099/mic.0.000538.

18. Barra, L., Barac, P., König, G.M., Crüsemann, M., Dickschat, J.S.: Volatiles from the fungal microbiome of the marine sponge Callyspongia cf. flammea. Org Biomol Chem. 2017, 15, 7411-7421.

17. Bruns, H.*, Crüsemann, M.*, Letzel, A.C., Alanjary, M., McInerney, J.O., Jensen, P.R., Schulz, S., Moore, B.S., Ziemert, N.: Function-related replacement of bacterial siderophore pathways. ISME J 2017 Aug 15. doi: 10.1038/ismej.2017.137.
* = Co-first author

16. Larson, C.B., Crüsemann, M., Moore, B.S.: PCR-Independent Method of Transformation-Associated Recombination Reveals the Cosmomycin Biosynthetic Gene Cluster in an Ocean Streptomycete. J Nat Prod. 2017 Mar 23. doi: 10.1021/acs.jnatprod.6b01121.

15. Crüsemann, M., O’Neill, E.C., Larson, C.B., Melnik, A.V., Floros, D.J., da Silva, R.R., Jensen, P.R., Dorrestein, P.C., Moore, B.S.: Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols. J Nat Prod. 2017 80, 588-597.

14. Hufendiek, P., Stölben, S.S., Kehraus, S., Merten, N., Harms, H., Crüsemann, M., Arslan, I., Gütschow, M., Schneider, T., König, G.M.: Biosynthetic Studies on Acetosellin and Structure Elucidation of a New Acetosellin Derivative. Planta Med. 2017 Jan 12. doi: 10.1055/s-0042-124493.

13. Dávila-Céspedes, A.*, Hufendiek, P.*, Crüsemann, M.*, Schäberle, T.F., König, G.M.: Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolites. Beilstein J Org Chem. 2016, 12, 969-84.

* = Co-first author

12. Wang, M., Carver, J.,Phelan, V.,Sanchez, L.M., Garg, N., Peng, Y., Nguyen, D.D., Watrous, J., Kapono, C.A., Luzzatto-Knaan, T., Porto, C., Bouslimani, A., Melnik, A.V., Meehan, M.J., Liu, W.-T., Crüsemann, M., Boudreau, P.D., Esquenazi, E., Sandoval-Calderón, M., Kersten, R.D., Pace, L.A., Quinn, R.A., Duncan, K.D., Hsu, C.-C., Floros, D.F., Gavilan, R., Kleigrewe, K., Northen, T., Dutton, R., Parrot, D., Carlson, E., Aigle, B., Michelsen, C., Jelsbak, L., Sohlenkamp, C., Pevzner, P., Edlund, A., McLean, J., Piel, J., Murphy, B., Gerwick, L., Liaw, C.-C., Yang, Y.-L., Humpf, H.-U., Mansson, M., Keyzers, R., Sims, A., Johnson, A., Sidebottom, A., Sedio, B., Klitgaard, A., Larson, C., Boya, C.A., Torres-Mendoza, D., Gonzalez, D., Silva, D., Marques, L., Demarque, D., Pociute, E., O'Neill, E., Briand, E., Helfrich, E., Granatosky, E., Glukhov, E., Ryffel, F., Houson, H., Mohimani, H., Kharbush, J., Zeng, J., Vorholt, J., Kurita, K., Charusanti, P., McPhail, K., Nielsen, K., Vuong, L., Elfeki, M., Traxler, M., Engene, N., Koyama, N., Vining, O., Baric, R., Silva, R., Mascuch, S., Tomasi, S., Jenkins, S., Macherla, V., Hoffmann, T., Agarwal, V., Williams, P., Dai, J., Neupane, R., Gurr, J., Rodríguez, A., Lamsa, A., Zhang, C., Dorrestein, K., Duggan, B., Almaliti, J.; Allard, P.-M., Phapale, P., Nothias, L.-F., Alexandrov, T., Litaudon, M., Wolfender, J.-L., Kyle, J., Metz, T., Peryea, T., Nguyen, D.-T., Leer, D. V., Shinn, P., Jadhav, A., Müller, R., Waters, K., Shi, W., Liu, X., Zhang, L., Knight, R., Jensen, P.R., Palsson, B., Pogliano, K., Linington, R., Gutiérrez, M., Lopes, N., Gerwick, W., Moore, B.S., Dorrestein, P.C., Bandeira, N.: Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nat. Biotechnol.2016, 34, 828–837.

highlighted in: Doerr, A.: Crowdsourcing for natural products research. Nature Methods 2016, 13, 812-813. Horsman, M.E., Boddy, C.N.: Natural products: Mapping an amazing thicket. Nat Chem Biol. 2016, 13, 6-7.

11. Cha, J.-Y., Han, S., Hong, H.-J., Cho, H., Kim, D., Kwon, Y., Kwon, S.-K., Crüsemann, M., Lee, Y.-B., Kim, J.F., Giaever, G., Nislow, C., Moore, B.S., Thomashow, L.S., Weller, D.M., Kwak, Y.-S.: Microbial and biochemical basis of a Fusarium wilt suppressive soil ISME J. 2016, 10, 119-29.

10. Awakawa, T., Crüsemann, M., Munguia, J., Ziemert, N., Nizet, V., Fenical, W., Moore, B.S.: Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase Chembiochem 2015, 16, 1443-1447.

9. Duncan, K.R.*, Crüsemann, M.*, Lechner, A.*, Sarkar, A., Li, J., Ziemert, N., Wang, M., Bandeira, N., Moore, B.S., Dorrestein, P.C., Jensen, P.R.: Molecular Networking and Pattern-Based Genome Mining Improves Discovery of Biosynthetic Gene Clusters and their Products from Salinispora Species. Chem Biol 2015, 22, 460-71.
* = Co-first author

8. Bonet, B., Teufel, R., Crüsemann, M., Ziemert, N., Moore B.S.: Direct capture and heterologous expression of Salinispora natural product genes for the biosynthesis of enterocin. J Nat Prod 2015, 78, 539-542.

7. Wilson, M.C., Mori, T., Rückert, C., Uria, A.R., Helf, M.J., Takada, K., Gernert, C., Steffens, U., Heycke, N., Schmitt, S., Rinke, C., Helfrich, E.J.N., Brachmann, A.O., Gurgui, C., Wakimoto, T., Kracht, M., Crüsemann, M., Hentschel, U., Abe, I., Matsunaga, S., Kalinowski, J., Takeyama, H., Piel, J.: Discovery of an environmental bacterial taxon with a large and distinct metabolic repertoire. Nature 2014, 506, 58-62.
highlighted in: Jaspars, M., Challis, G.: Microbiology: A talented genus. Nature 2014, 506, 38-39.

6. Schmidt, Y., van der Voort, M., Crüsemann, M., Piel, J., Josten, M., Sahl, H.-G., Miess, H., Raaijmakers, J.M., Gross, H.: Biosynthetic origin of the antibiotic cyclocarbamate brabantamide A (SB-253514) in plant-associated Pseudomonas. Chembiochem 2014, 15, 259–266.

5. Bouhired, S.M., Crüsemann, M., Almeida, C., Weber, T., Piel, J,. Schäberle, T.F, König, G.M.: Biosynthesis of phenylnannolone A, a MDR reversal agent from the halotolerant myxobacterium Nannocystis pusilla B150.  Chembiochem 2014, 15, 757-765.

4. Bäcker, C., Jenett-Siems. K., Siems, K., Wurster, M., Bodtke, A., Chamseddin, C., Crüsemann, M., Lindequist, U.: Triterpene glycosides from the leaves of Pittosporum angustifoliumPlanta Med 2013 79, 1461-1469.

3. Cai, X., Teta, R., Kohlhaas, C., Crüsemann, M., Ueoka, R., Mangoni, A., Freeman, M.F., Piel, J.: Manipulation of regulatory genes reveals complexity and fidelity in hormaomycin biosynthesis. Chem Biol 2013 20 (6) 839-846.

2. Crüsemann, M., Kohlhaas, C., Piel, J.: Evolution-guided engineering of nonribosomal peptide synthetase adenylation domains Chem Sci 2013 (4) 1041-1045.

1. Höfer, I., Crüsemann, M., Radzom, M., Geers, B., Flachshaar, D., Cai, X., Zeeck, A., Piel, J.: Insights into the biosynthesis of hormaomycin, an exceptionally complex bacterial signaling metabolite. Chem Biol 2011 18 (3) 381-391.

highlighted in: Jones, A.C., Monroe, E.A., Gerwick, W.H.: Elegant metabolite biosynthesis. Chem Biol 2011 18 (3) 281-283.

 
 

 

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